Studies on the pathological effects of fipronil and their amelioration by curcumin in rats (Record no. 27955)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03027nam a2200181Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20220325144728.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 140128s9999 xx 000 0 und d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 636.0896 |
| Item number | SEN/ST PG |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Senthilkumar T |
| 245 ## - TITLE STATEMENT | |
| Title | Studies on the pathological effects of fipronil and their amelioration by curcumin in rats |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Mannuthy |
| Name of publisher, distributor, etc. | Centre of Excellence in Pathology, College of Veterinary and Animal Sciences |
| Date of publication, distribution, etc. | 2010 |
| 502 ## - DISSERTATION NOTE | |
| Degree type | MVSc |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | The present study entitled ‘Pathological effects of Fipronil and their amelioration by curcumin in rats’ was undertaken by administering with fipronil in group I animals and both fipronil and curcumin in group II animals for 28 days. Group III administered with honey served as control. The weekly body weights, clinical signs, haematology, biochemical parameters, mortality pattern, gross pathology and histopathology of various organs were analysed to study the effect. The oxidative damage of the liver was assessed by the estimation of lipid peroxides, reduced glutathione and superoxide dismutase. A significant decrease in the mean body weights was observed in group I and II. ALT, AST, cholesterol and creatinine levels showed a significant increase in the group I and significantly lower levels in group II. Total protein, albumin, globulin, PCV and Hb levels were significantly lower in group I but significantly higher in group II. TLC, ESR and DLC revealed no variation. Group I showed significantly higher lipid peroxides and lower glutathione and superoxide dismutase levels in the liver. Group II showed significantly lower lipid peroxides and higher glutathione and superoxide dismutase levels in the liver. The animals showed dullness and inappetance in the treatment groups. Mortalities were observed in both groups. Hepatomegaly and focal necrotic spots in the liver, enlargement of thyroid were the major gross lesions in group I. Gross lesions were less in group II. Smaller and cystic dilatation of acini, hyperplasia and fibrosis of thyroid, necrosis, hypertrophy and individualization of hepatocytes, tubular and glomerular degeneration and necrosis of the kidney, alveolar septal thickening, peribronchial lymphoid cell hyperplasia and bronchostenosis of the lung, predominance red pulp of spleen, desquamation and fusion of villi and goblet cell hyperplasia in the intestine, hyalinization of cardiac muscle fibers were observed in group I animal. Uniform sized follicular acini of thyroid, prominent kupffer cell reaction of hepatocytes,mild degeneration of tubules of kidney, predominance of white pulp of spleen, glial cell response in the brain, glandular hyperplasia of intestine were the major findings in group II animals. The study revealed that fipronil is thyrotoxic, hepatotoxic and nephrotoxic to rats and curcumin has good ameliorating effect against fipronil toxicity. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Divakaran Nair N (Guide) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://krishikosh.egranth.ac.in/handle/1/5810110296 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Theses |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| KAU Central Library, Thrissur | KAU Central Library, Thrissur | Theses | 2014-03-18 | 636.0896 SEN/ST PG | 173016 | 2014-03-18 | 2014-03-18 | Theses |