Pathology Of Experimental Hypothyroidism In Goats
By: Sreekumaran T.
Contributor(s): Rajan A (Guide).
Material type:
BookPublisher: Mannuthy Department of Pathology, College of Veterinary and Animal Sciences 1979DDC classification: 636.089 6 Online resources: Click here to access online Dissertation note: MVSc Abstract: An experimental model of hypothyroid state was induced in kids, using different dose regimes of thiourea with the objective of studying sequence of clinic – pathological changes in different levels of hypothyroidism and its influence on the animal health and growth.
Twelve cross – bred clinically healthy kids of the age group between 3 – 4 months were employed for the study. The animals were randomly divided into a control group of four animals and experimental group of eight animals. Experimental hypothyroidism was induced by feeding thiourea at the dose levels of 100 g, 150 g, 200 g and 250 g per kg body weight. Haemogram, body weight, plasma proteins, serum cholesterol and PBI values were estimated at periodic intervals. The kids were subjected to detailed autopsy after death/sacrifice. Gross lesions were recorded and detailed histopathological examination of tissues was carried out employing special stains wherever necessary.
During the course of observation for a period of three months all the kids dosed with thiourea died at varying intervals except the kids in the lowest dosage group. There was stunting of growth and appreciable reduction in weight of the animals. Weakness, lethargy, depression, reduction in feed intake, sub- cutaneous oedema of varying degree were the important clinical features observed.
There was significant increase in blood cholesterol values and plasma protein levels in thiourea dosed kids. A significant reduction in serum PBI was also recorded. There was significant increase in the relative weight of thyroid, adrenal and pituitary glands of animals in the experimental group. Gelatinisation of subcutaneous fat and hypertrophy and dilatation of the left ventricle were common findings at autopsy. Histologically the thyroid glands exhibited varying degree of hyperplastic changes and depletion of colloid in the follicles. Hyperplasia and hypertrophy of lining epithelium was also observed. Predominant histological change in the pituitary was hyperplasia and hypertrophy of basophil cells and degenerative changes in the acidophils. Hepatic lipidosis was a common observation. Histological lesions in the skin were similar to that reported in human myxoedema. Adrenal glands showed hypertrophy, depletion of fat and focal areas of haemorrhage in the zona fasiculata. In all the hypothyroid kids, varying degrees of degenerative changes were observed in the gonads indicating that in hypothyroidism fertility will be seriously affected.
| Item type | Current location | Call number | Status | Date due | Barcode |
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Theses
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KAU Central Library, Thrissur Theses | 636.089 6 SRE/PA (Browse shelf) | Available | 170020 |
MVSc
An experimental model of hypothyroid state was induced in kids, using different dose regimes of thiourea with the objective of studying sequence of clinic – pathological changes in different levels of hypothyroidism and its influence on the animal health and growth.
Twelve cross – bred clinically healthy kids of the age group between 3 – 4 months were employed for the study. The animals were randomly divided into a control group of four animals and experimental group of eight animals. Experimental hypothyroidism was induced by feeding thiourea at the dose levels of 100 g, 150 g, 200 g and 250 g per kg body weight. Haemogram, body weight, plasma proteins, serum cholesterol and PBI values were estimated at periodic intervals. The kids were subjected to detailed autopsy after death/sacrifice. Gross lesions were recorded and detailed histopathological examination of tissues was carried out employing special stains wherever necessary.
During the course of observation for a period of three months all the kids dosed with thiourea died at varying intervals except the kids in the lowest dosage group. There was stunting of growth and appreciable reduction in weight of the animals. Weakness, lethargy, depression, reduction in feed intake, sub- cutaneous oedema of varying degree were the important clinical features observed.
There was significant increase in blood cholesterol values and plasma protein levels in thiourea dosed kids. A significant reduction in serum PBI was also recorded. There was significant increase in the relative weight of thyroid, adrenal and pituitary glands of animals in the experimental group. Gelatinisation of subcutaneous fat and hypertrophy and dilatation of the left ventricle were common findings at autopsy. Histologically the thyroid glands exhibited varying degree of hyperplastic changes and depletion of colloid in the follicles. Hyperplasia and hypertrophy of lining epithelium was also observed. Predominant histological change in the pituitary was hyperplasia and hypertrophy of basophil cells and degenerative changes in the acidophils. Hepatic lipidosis was a common observation. Histological lesions in the skin were similar to that reported in human myxoedema. Adrenal glands showed hypertrophy, depletion of fat and focal areas of haemorrhage in the zona fasiculata. In all the hypothyroid kids, varying degrees of degenerative changes were observed in the gonads indicating that in hypothyroidism fertility will be seriously affected.
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