Incidence And Pathological Features Of Hypothyroidism In Cattle
By: Mammen J Abraham.
Contributor(s): Valsala K V (Guide).
Material type:
BookPublisher: Mannuthy Department of Pathology, College of Veterinary and Animal Sciences 1986Description: .DDC classification: 636.089 6 Online resources: Click here to access online Dissertation note: MVSc Abstract: A survey study conducted indicated that hypothyroidism was one of the major etiological factors responsible for non – infectious reproductive disorders in cattle. The reason for repeat breeding cases in certain instances could be traced to hypofunction of the thyroid gland. Besides, this, hypothyroidism was experimentally induced in six male calves using thiourea as the goitrogen at a single dosage schedule of 150 mg/kg body weight with a view to delineate the sequence of clinicopathological changes in the sub – clinical hypothyroid state. The haemogram, plasma protein level, serum cholesterol level and serum protein bound iodine level of these animals were estimated at fortnightly intervals.
Clinically, the experimental animals manifested progressive weakness, dullness, reduction in feed intake, irregular shedding of hair, subcutaneous edema and above all a marked stunting in growth. Gelatinization of subcutaneous and other depot fat and cardiac dilatation were the chief lesions encountered at autopsy. The calves became progressively anaemic and registered high serum cholesterol and plasma protein levels but significantly low PBI level as compared with control claves. There was significant increase in the relative weights of the thyroid, adrenal and pituitary glands but reduction in the relative weight of the testis.
Histologically the thyroid follicular epithelial cells exhibited hyperplastic changes and varying degrees of degeneration along with significant depletion of colloid. Microscopically pituitary gland revealed vacuolation and hyperplasia of the basophil cells in focal areas. Adrenal glands showed slight proliferation of cells of zona faciculata and depletion of fat. Microscopic picture of the testis showed slight obliteration of the seminiferous tubules with no evidence of mitotic activity in the tubular cells. A few degenerated and desquamated cells were seen along with giant cells. The varying degrees of degenerative changes observed in the testis accounted for the reproductive disorders in hypothyroidism.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
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KAU Central Library, Thrissur Theses | 636.089 6 MAM/IN (Browse shelf) | Available | 170147 |
MVSc
A survey study conducted indicated that hypothyroidism was one of the major etiological factors responsible for non – infectious reproductive disorders in cattle. The reason for repeat breeding cases in certain instances could be traced to hypofunction of the thyroid gland. Besides, this, hypothyroidism was experimentally induced in six male calves using thiourea as the goitrogen at a single dosage schedule of 150 mg/kg body weight with a view to delineate the sequence of clinicopathological changes in the sub – clinical hypothyroid state. The haemogram, plasma protein level, serum cholesterol level and serum protein bound iodine level of these animals were estimated at fortnightly intervals.
Clinically, the experimental animals manifested progressive weakness, dullness, reduction in feed intake, irregular shedding of hair, subcutaneous edema and above all a marked stunting in growth. Gelatinization of subcutaneous and other depot fat and cardiac dilatation were the chief lesions encountered at autopsy. The calves became progressively anaemic and registered high serum cholesterol and plasma protein levels but significantly low PBI level as compared with control claves. There was significant increase in the relative weights of the thyroid, adrenal and pituitary glands but reduction in the relative weight of the testis.
Histologically the thyroid follicular epithelial cells exhibited hyperplastic changes and varying degrees of degeneration along with significant depletion of colloid. Microscopically pituitary gland revealed vacuolation and hyperplasia of the basophil cells in focal areas. Adrenal glands showed slight proliferation of cells of zona faciculata and depletion of fat. Microscopic picture of the testis showed slight obliteration of the seminiferous tubules with no evidence of mitotic activity in the tubular cells. A few degenerated and desquamated cells were seen along with giant cells. The varying degrees of degenerative changes observed in the testis accounted for the reproductive disorders in hypothyroidism.
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