Immunopathological Response of the Duck (Anas PLatyrrhyncos Domesticus) to Sublethal Dose of Selected Agro-Chemicals
By: Vijayan N.
Contributor(s): Valsala K V(Guide).
Material type:
BookPublisher: Mannuthy Centre of Excellence in Pathology, College of Veterinary and Animal Sciences 1998DDC classification: 636.089 6 Online resources: Click here to access online | Click here to access online Dissertation note: PhD Abstract: The study was conducted with the objective of assessing
the teratologic, embryotoxic and immunopathologic effects of
two agro-chemicals carbofuran and 2,4-D used in agricultural
operations, on duck embryos and ducklings.
The embryological studies included the observation on the
embryonic defects and weight of the lymphoid organs along with
the histopathologic and ultrastructural studies of the
lymphoid organs like the bursa, spleen and thymus.
The results showed that the contamination of the eggs
with the above chemicals caused moderate deleterious effects
on the lymphoid system, though no teratologic effects could be
observed. The histological and ultrastructural changes also
confirmed the deleterious effects at the tissue and cellular
level.
The immune system of the ducks exposed to the above
chemicals for two different durations were assessed using a
battery of tests. The humoral immune system was assessed
based on the body weight, lymphoid organ weight,
haematological evaluation, serum biochemical evaluation and
the evaluation of HI titre against NDV.
The cell-mediated immune system was assessed by the skin
reactivity tests to DNCB and PHA.
LMIT and GVHR were also
employed to assess the cell-mediated immune system. The
histological and ultrastructural studies were also conducted
after six weeks and ten weeks of the experiment. The
assessment of the immunological profile employing these
elegant tests revealed that these agro-chemicals caused mild
but significant suppression of the cell-mediated and humoral
immune response.
By this investigation it was clarified that these
agro-chemicals have mild to moderate degree of immunotoxic
effect when exposed for a short duration, but the changes were
severe when exposed for longer duration. From the studies, it
was demonstrated that the immunotoxic effect of carbofuran is
more compared to 2,4-D (herbicide) and the changes were dose
and time dependent.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
|
KAU Central Library, Thrissur Theses | 636.089 6 VIJ/IM (Browse shelf) | Available | 171402 |
PhD
The study was conducted with the objective of assessing
the teratologic, embryotoxic and immunopathologic effects of
two agro-chemicals carbofuran and 2,4-D used in agricultural
operations, on duck embryos and ducklings.
The embryological studies included the observation on the
embryonic defects and weight of the lymphoid organs along with
the histopathologic and ultrastructural studies of the
lymphoid organs like the bursa, spleen and thymus.
The results showed that the contamination of the eggs
with the above chemicals caused moderate deleterious effects
on the lymphoid system, though no teratologic effects could be
observed. The histological and ultrastructural changes also
confirmed the deleterious effects at the tissue and cellular
level.
The immune system of the ducks exposed to the above
chemicals for two different durations were assessed using a
battery of tests. The humoral immune system was assessed
based on the body weight, lymphoid organ weight,
haematological evaluation, serum biochemical evaluation and
the evaluation of HI titre against NDV.
The cell-mediated immune system was assessed by the skin
reactivity tests to DNCB and PHA.
LMIT and GVHR were also
employed to assess the cell-mediated immune system. The
histological and ultrastructural studies were also conducted
after six weeks and ten weeks of the experiment. The
assessment of the immunological profile employing these
elegant tests revealed that these agro-chemicals caused mild
but significant suppression of the cell-mediated and humoral
immune response.
By this investigation it was clarified that these
agro-chemicals have mild to moderate degree of immunotoxic
effect when exposed for a short duration, but the changes were
severe when exposed for longer duration. From the studies, it
was demonstrated that the immunotoxic effect of carbofuran is
more compared to 2,4-D (herbicide) and the changes were dose
and time dependent.
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