Dicofol toxicity in Rats
By: Padmaraj P K.
Contributor(s): Venugopalan K (Guide).
Material type:
BookPublisher: Mannuthy Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences 2001DDC classification: 636.0895 Online resources: Click here to access online Dissertation note: MVSc Abstract: An experiment was conducted to assess the toxicity of
dicofol in rats. A group of ninety adult rats weighing 150-200g of
either sex were included in five groups as the control groups
consisting of 10 rats of either sex and the experimental groups
consisting of 20 rats of either sex, in each group.
Dicofol was administered orally, once daily for three
months to the experimental Groups Il, III and IV at the dose rate
of 50 mg/kg, 75 mg/kg and 100mg/kg respectively. Group V was
sprayed 0.1 per cent dicofol, once daily for three months.
, .
The main items of observation included clinical
symptoms of dicofol toxicity and assessment of body weight. The
clinical signs were evident in the experimental groups. Dicofol
caused skin irritation when applied externally. The percentage of
mortality was 5-10 in the experimental groups. The rats of
experimental gro~ps showed a marked loss of appetite which
resulted in decrease in body weight.
The detection of dicofol by thin layer chromatography
in liver, heart and kidney tissues showed their presence in these
organs. This indicated the toxicity of dicofol to these organs.
Necropsy study conducted revealed both gross and
microscopic lesions in the tissues of liver, heart and kidney. The
haematological parameters showed no variation in values from that
of the normal.
The study revealed a note of caution to the wide
. spread use of dicofol as insecticide.
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|---|---|---|---|---|---|
Theses
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KAU Central Library, Thrissur Theses | 636.0895 PAD/DI (Browse shelf) | Available | 171887 |
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MVSc
An experiment was conducted to assess the toxicity of
dicofol in rats. A group of ninety adult rats weighing 150-200g of
either sex were included in five groups as the control groups
consisting of 10 rats of either sex and the experimental groups
consisting of 20 rats of either sex, in each group.
Dicofol was administered orally, once daily for three
months to the experimental Groups Il, III and IV at the dose rate
of 50 mg/kg, 75 mg/kg and 100mg/kg respectively. Group V was
sprayed 0.1 per cent dicofol, once daily for three months.
, .
The main items of observation included clinical
symptoms of dicofol toxicity and assessment of body weight. The
clinical signs were evident in the experimental groups. Dicofol
caused skin irritation when applied externally. The percentage of
mortality was 5-10 in the experimental groups. The rats of
experimental gro~ps showed a marked loss of appetite which
resulted in decrease in body weight.
The detection of dicofol by thin layer chromatography
in liver, heart and kidney tissues showed their presence in these
organs. This indicated the toxicity of dicofol to these organs.
Necropsy study conducted revealed both gross and
microscopic lesions in the tissues of liver, heart and kidney. The
haematological parameters showed no variation in values from that
of the normal.
The study revealed a note of caution to the wide
. spread use of dicofol as insecticide.
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