Nephroprotective effect of Aerva Lanata (Cherula) and Boerrhavia Diffusa (* Thazhuthama) in rats
By: Fakrudeen Ali Ahamed N.
Contributor(s): Venugopalan K (Guide).
Material type:
BookPublisher: Mannuthy Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences 2003DDC classification: 636.089 5 Online resources: Click here to access online Dissertation note: MVSc Abstract: An experiment was conducted to assess the nephroprotective effect of
Aerva lanata (Cherula) and Boerrhavia diffusa (Thazhuthama) against
gentamicin induced nephrotoxicity in rats. A group of 48 adult albino rats
weighing 150-250 g of either sex were include in six groups and each group
consisting of eight rats.
All the experimental groups except. saline control (G I) were given
gentamicin sulphate (80 mglkg/day subcutaneously) for 12 days. After 12 days,
the experimental groups (G3, G4, G5 and G6) were given two selected doses
[(G3 and G5 - 250 rng/kgjand (G4 and G6 - 500 mg/kg)] of dried alcoholic
extract of Aerva lanata and Boerrhavia difJusa orally, for a period of another 21
days respectively.
Feed intake and body weight was reduced in gentamicin administered
groups (G2, G3, G4, G5 and G6) at I ih day and it was reverted to normal at 33rd
day (G3, G4, G5 and G6). .
Elevated blood urea nitrogen (1 ih day) was reverted to normal at 26th day
in Aerva lanata @ 250 and -500 mg/kg (G3 and G4) and at 33rd day in Boerrhavia
diffusa @ 250 and 500 mg/kg (G5 and G6) respectively.
Microscopical examination of urine at 33rd day, revealed the initiation of
regeneration of renal epithelium.
The severity of gross and microscopical lesions of kidney observed at 12th
day was minimized at 33rd day, indicate the nephroprotective effect of Aerva
lanata and Boerrhavia diffusa.
The change in haemogram at I z" day (reduced total leukocyte count,
neutrophil count and increased Iymphocyte count) was reverted to normal in all
the groups at 33rd day.
Hence the study confirmed that Aerva lanata and Boerrhavia diffusa
posses nephroprotective action and it could be used as nephroprotective agents .
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KAU Central Library, Thrissur Theses | 636.089 5 FAK/NE (Browse shelf) | Available | 172161 |
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MVSc
An experiment was conducted to assess the nephroprotective effect of
Aerva lanata (Cherula) and Boerrhavia diffusa (Thazhuthama) against
gentamicin induced nephrotoxicity in rats. A group of 48 adult albino rats
weighing 150-250 g of either sex were include in six groups and each group
consisting of eight rats.
All the experimental groups except. saline control (G I) were given
gentamicin sulphate (80 mglkg/day subcutaneously) for 12 days. After 12 days,
the experimental groups (G3, G4, G5 and G6) were given two selected doses
[(G3 and G5 - 250 rng/kgjand (G4 and G6 - 500 mg/kg)] of dried alcoholic
extract of Aerva lanata and Boerrhavia difJusa orally, for a period of another 21
days respectively.
Feed intake and body weight was reduced in gentamicin administered
groups (G2, G3, G4, G5 and G6) at I ih day and it was reverted to normal at 33rd
day (G3, G4, G5 and G6). .
Elevated blood urea nitrogen (1 ih day) was reverted to normal at 26th day
in Aerva lanata @ 250 and -500 mg/kg (G3 and G4) and at 33rd day in Boerrhavia
diffusa @ 250 and 500 mg/kg (G5 and G6) respectively.
Microscopical examination of urine at 33rd day, revealed the initiation of
regeneration of renal epithelium.
The severity of gross and microscopical lesions of kidney observed at 12th
day was minimized at 33rd day, indicate the nephroprotective effect of Aerva
lanata and Boerrhavia diffusa.
The change in haemogram at I z" day (reduced total leukocyte count,
neutrophil count and increased Iymphocyte count) was reverted to normal in all
the groups at 33rd day.
Hence the study confirmed that Aerva lanata and Boerrhavia diffusa
posses nephroprotective action and it could be used as nephroprotective agents .
••
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