Comparative seroconversion of Foot-And-Mouth disease vaccines in goats
By: Madhanmohan M.
Contributor(s): Tresamol P V (Guide).
Material type:
BookPublisher: Mannuthy Department of Veterinary Epidemiology and Preventive Medicine, College of Veterinary and Animal Sciences 2003DDC classification: 636.0894 Online resources: Click here to access online Dissertation note: MVSc Abstract: The comparative seroconversions of two different foot-and-mouth disease
vaccines in goats were studied. Group I animals were vaccinated with inactivated
quadrivalent aluminium hydroxide gel saponin adjuvanted FMD vaccine. Group
11 animals were vaccinated with inactivated quadrivalent FMD oil-adjuvant
vaccine as per the manufacture's schedule. Vaccinations were done in
unvaccinated goats above four month of age. The antibody titre against foot and
mouth disease virus types 0, A, C and Asia-I were assessed by liquid phase
blocking ELISA.
Group I animals showed the protective titre of type ° antibody titres
throughout the period except sixth, tenth, eleventh and twelfth month. Group 11
animals showed the protective level throughout the study period except seventh,
eighth and ninth month.
Both the groups showed the protective titre of type A, C and Asia-I
antibody titres throughout the study period up to 12 months. All the vaccination
including primary and booster vaccinations produce increase in antibody titre.
Both the groups did not show any significant variation in antibody titres
against FMDV type 0, A, C and Asia-I except the time of booster vaccination.
Kids born from both the ~roups showed the protective level of type °
maternal antibody only upto one week of age where as protective level for type A
and C maternal antibodies upto four weeks of age.
Group I kids maintained the protective level of type Asia-I upto two
weeks of age where as Group 11 maintained upto three weeks of age.
From this observation it is concluded that
1. Both the group of vaccine provides sufficient protective titre for FMDV
type 0, A, C and Asia-l .
2. Aluminium hydroxide gel vaccine performance is equally good as that of
oil adjuvanted vaccine.
3. Oil-adjuvanted vaccine reduces labour cost for injection, number of visit
and stress to the animals to a very ?reat extent. Therefore oil-adjuvanted
vaccine may be preferred when compared to gel vaccine.
4. The maternal antibody protect the kids which were born to vaccinated
does one to four weeks of age, regardless of the adjuvant used in the
vaccine.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
|
KAU Central Library, Thrissur Theses | 636.0894 MAD/CO (Browse shelf) | Available | 172238 |
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MVSc
The comparative seroconversions of two different foot-and-mouth disease
vaccines in goats were studied. Group I animals were vaccinated with inactivated
quadrivalent aluminium hydroxide gel saponin adjuvanted FMD vaccine. Group
11 animals were vaccinated with inactivated quadrivalent FMD oil-adjuvant
vaccine as per the manufacture's schedule. Vaccinations were done in
unvaccinated goats above four month of age. The antibody titre against foot and
mouth disease virus types 0, A, C and Asia-I were assessed by liquid phase
blocking ELISA.
Group I animals showed the protective titre of type ° antibody titres
throughout the period except sixth, tenth, eleventh and twelfth month. Group 11
animals showed the protective level throughout the study period except seventh,
eighth and ninth month.
Both the groups showed the protective titre of type A, C and Asia-I
antibody titres throughout the study period up to 12 months. All the vaccination
including primary and booster vaccinations produce increase in antibody titre.
Both the groups did not show any significant variation in antibody titres
against FMDV type 0, A, C and Asia-I except the time of booster vaccination.
Kids born from both the ~roups showed the protective level of type °
maternal antibody only upto one week of age where as protective level for type A
and C maternal antibodies upto four weeks of age.
Group I kids maintained the protective level of type Asia-I upto two
weeks of age where as Group 11 maintained upto three weeks of age.
From this observation it is concluded that
1. Both the group of vaccine provides sufficient protective titre for FMDV
type 0, A, C and Asia-l .
2. Aluminium hydroxide gel vaccine performance is equally good as that of
oil adjuvanted vaccine.
3. Oil-adjuvanted vaccine reduces labour cost for injection, number of visit
and stress to the animals to a very ?reat extent. Therefore oil-adjuvanted
vaccine may be preferred when compared to gel vaccine.
4. The maternal antibody protect the kids which were born to vaccinated
does one to four weeks of age, regardless of the adjuvant used in the
vaccine.
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