Antipyretic and CNS activity of seeds from red and white types of lotus (nelumbo nucifera) in albino rats
By: Deepa P K.
Contributor(s): Usha P T A (Guide).
Material type:
BookPublisher: Mannuthy Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences 2006Description: 65.DDC classification: 636.089 5 Online resources: Click here to access online Dissertation note: MVSc Abstract: The antipyretic and CNS activity of the extract of the seeds of red and white Nelumbo nucifera was studied in albino rats. Qualitiative tests for the detection of phytochemicals showed the presence of steroids, alkaloids, flavonoids, glycosides, phenolic compounds, diterpenes, triterpenes and saponins. Pyrexia was induced by subcutaneous injection of 20% Brewer’s yeast suspension. Group I served as pyrexia control, group II was administered aspirin at the dose rate of 100 mg/kg body weight, Group III and IV with extract of red lotus seed and group V and VI with extract of white lotus seed at the dose rate of 400 and 600 mg/kg body weight respectively. The body temperature was recorded from zeroth to fifth hour at one hour interval. Haematological parameters and Serum ALT, AST levels were estimated at peak of pyrexia and five hours after drug administration.
For CNS study group I was kept as normal control, Group II was administered chlorpromazine at the dose rate of 7 mg/kg body weight. Group III , IV V and VI were treated as in the case of antipyretic study. Actaphotometer and Rotarod were used to assess the spontaneous and forced motor activities respectively. Haematological parameters and serum ALT, AST levels were estimated at peak of tranquillization.
The extract of white lotus seed at dose rate of 600 mg/kg body weight showed maximum antipyretic effect followed by red lotus at 600 mg/kg body weight and white lotus at the rate of 400 mg/kg body weight among the treatment groups. By the fifth hour the effect of white lotus seed extract at the dose rate of 600 mg/kg body weight was comparable to that of standard drug aspirin.
Eventhough the extract of red lotus at the dose rate of 600 mg/kg body weight inhibited the spontaneous motor activity to the maximum initially, the extracts were found to be equipotent after 120 minutes of drug administration. But the activity was less when compared with the standard drug chlorpromazine. Comparison of the treatment groups showed that group IV showed maximum inhibition of forced motor activity followed by group VI and group III.
The haematological and biochemical parameters assessed were within the normal range in both studies.
From the present study it can be concluded that the extracts of red and while lotus seeds possessed potent antipyretic and CNS effects. The extract from the seeds of white lotus showed more potent CNS activity where as both the extracts were showing equipotent tranquillizing property.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
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KAU Central Library, Thrissur Theses | 636.089 5 DEE/AN (Browse shelf) | Available | 172584 |
MVSc
The antipyretic and CNS activity of the extract of the seeds of red and white Nelumbo nucifera was studied in albino rats. Qualitiative tests for the detection of phytochemicals showed the presence of steroids, alkaloids, flavonoids, glycosides, phenolic compounds, diterpenes, triterpenes and saponins. Pyrexia was induced by subcutaneous injection of 20% Brewer’s yeast suspension. Group I served as pyrexia control, group II was administered aspirin at the dose rate of 100 mg/kg body weight, Group III and IV with extract of red lotus seed and group V and VI with extract of white lotus seed at the dose rate of 400 and 600 mg/kg body weight respectively. The body temperature was recorded from zeroth to fifth hour at one hour interval. Haematological parameters and Serum ALT, AST levels were estimated at peak of pyrexia and five hours after drug administration.
For CNS study group I was kept as normal control, Group II was administered chlorpromazine at the dose rate of 7 mg/kg body weight. Group III , IV V and VI were treated as in the case of antipyretic study. Actaphotometer and Rotarod were used to assess the spontaneous and forced motor activities respectively. Haematological parameters and serum ALT, AST levels were estimated at peak of tranquillization.
The extract of white lotus seed at dose rate of 600 mg/kg body weight showed maximum antipyretic effect followed by red lotus at 600 mg/kg body weight and white lotus at the rate of 400 mg/kg body weight among the treatment groups. By the fifth hour the effect of white lotus seed extract at the dose rate of 600 mg/kg body weight was comparable to that of standard drug aspirin.
Eventhough the extract of red lotus at the dose rate of 600 mg/kg body weight inhibited the spontaneous motor activity to the maximum initially, the extracts were found to be equipotent after 120 minutes of drug administration. But the activity was less when compared with the standard drug chlorpromazine. Comparison of the treatment groups showed that group IV showed maximum inhibition of forced motor activity followed by group VI and group III.
The haematological and biochemical parameters assessed were within the normal range in both studies.
From the present study it can be concluded that the extracts of red and while lotus seeds possessed potent antipyretic and CNS effects. The extract from the seeds of white lotus showed more potent CNS activity where as both the extracts were showing equipotent tranquillizing property.
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