Abstract:
A total of 214 specimens which inoculated 80 lung tissues, 55 nasal swabs, 43 tracheal swabs and 36 bronchial lymph nodes from goats with signs of pneumonia were examined during the course of this study. Out of these, 139 revealed the presence of different species of bacterial organisms. One – hundred and fifty six strains of various bacterial species were isolated and identified. The important species being Pasteurella multocida, Streptococcus pneumonia, Streptococcus Pyogenes, Corynebacterium pyogenes, Staphylococcs aureus, Klebsiella pneumonia and Escherichia coli.
On experimental transmission study it was observed that P. multocida and Str. Pneumononiae were found to be lethal to mice and rabbits whereas C. pyogenes could produce only suppurative changes in omentum and liver.
Intra tracheal inoculation of the cultures of P. multocida, Str.pneumoniae and C. pyogenes in goats have revealed the reproduction of mild pneumonic changes, but did not produce death due to pneumonia. As time advanced these earlier changes showed a tendency towards healing. Compared to P. multocida and Str. Pneumonia it could be said that C. pyogenes had produced more intense tissue reaction in the lung under identical conditions.
In vitro antibiotic sensitivity studies of P. multocida, Str. Pneumonia and C. pyogenes to 11 chemotherapeutic agents were carried out. The agents included were ampicillin, bacitracin, chloramphenicol, erythromycin, gentamycin, kanamycin, nitrofurans, penicillin, streptomycin, tetracycline and triple sulfa. In the light of the results obtained it could be stated that the drugs of choice for P. multocida are nitrofurans, chloramphenicol and tetracycline. In the case of Str. Pneumonia, penicillin, chloramphenicol and bacitracin were found to be more effective and for C. pyogenes, ampicillin, chloramphenicol and penicillin showed cent percent sensitivity.
