Assessment of the antifertility property of ocimum sanctum

Abstract

A study was carried out in rats, to assess the antifertility property of the benzene fraction of the leaves of the plant Ocimum sanctum. Premating treatment was done in female animals at does levels of 200 and 400 mg per kilogram body weight for a duration of eight days. Male animals were subjected to the treatment at a dose level of 200 mg per kilogram body weight for 20 days . The experimental animals were allowed to mate with untreated animals of the opposite sex. Histopathological examination of the organs – pituitary, ovary, tests, liver and kidney were carried out.

Results of the study suggested considerable reduction of fertility in both the sexes. This can be attributed to the impaired release of gonadotrophic hormones and the resulting improper functioning of the gonads. Administration of the extract showed no toxic effects in the treated rats as well as in their offspring.