Browsing by Author "Padmaja, P B"

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    Pathogenesis and treatment of immature Ascaridia galli infection in experimentally infected chicken
    (Department of Parasitology, College of Veterinary and Animal Sciences, Mannuthy, 1992) Padmaja, P B; Sathianesan, V
    In a study conducted on the pathogenesis and treatment of Ascaridia galli in experimentally infected chicken at different developmental stages of the worm, it had been found that droopiness, whitish diarrhoea, marked reduction in body weight gain, haemorrhage and congestion at different parts of the intestinal mucosa and frothy or blood tinged intestinal contents were the main clinico pathological changes. Histopathological observations in the small intestine were signs of enteritis, jcatarrhalj changes, villar proliferation, desquamation of sub epithelium and villar tips and mild congestion and haemorrhage. A tissue phase was observed in the life-cycle of the nematode at 20th day post infection indicated by the presence of cut sections of the larvae-in the mucosal and submucosal regions. Haematologically, a decrease in the total erythrocyte count, an initial leucopenia followed by leucocytosis, reduction in packed cell volume and percentage of haemoglobin, an increase in the erythrocyte sedimentation rate, percentage of heterophils, eosinophils, mean corpuscular volume and mean corpuscular haemoglobin values and a reduction in the percentage of lymphocytes, monocytes and "mean corpuscular .haemoglobin concentration and an initial basopenia followed by basophilia were observed in infected chicks. For treatment, out of the four anthelmintics tried, namely piperazine hydrate, albendazole, morantel citrate and ivermectin against the infection, albendazole at 50 mg/kg body weight was found to be the most effective, closely followed by morantel citrate at 50 mg/kg body weight and then piperazine hydrate at 500 rag/kg ' body weight. I I Ivermectin at 1 mg/kg body weight subcutaneously was found to be the least effective. The present study with morantel citrate appeared to be the first of its kind as far as it's use against ascairidiasis in poultry was concerned