Studies on the Effect of Corticosteroids, Neostigmine and Calcium in Cobra Venom (Naja naja) Intoxication (Record no. 24981)
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| 000 -LEADER | |
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| fixed length control field | 02536nam a2200181Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20210709145258.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 140128s9999 xx 000 0 und d |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 636.089 5 |
| Item number | VEN/ST |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Venugopalan K |
| 245 ## - TITLE STATEMENT | |
| Title | Studies on the Effect of Corticosteroids, Neostigmine and Calcium in Cobra Venom (Naja naja) Intoxication |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. (IMPRINT) | |
| Place of publication, distribution, etc. | Mannuthy |
| Name of publisher, distributor, etc. | Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences |
| Date of publication, distribution, etc. | 1975 |
| 502 ## - DISSERTATION NOTE | |
| Degree type | MVSc |
| 520 3# - SUMMARY, ETC. | |
| Summary, etc. | Administration of specific antiserum as early as possible after snake bite is of utmost importance for better chances of survival. Supportive measures are definitely capable of reducing the venom toxicity And prolonging survival period eg., if the absorption of venom from the site of bite could be delayed or retarded it will be highly beneficial to the patient. It has been shown that certain drugs are capable of decreasing capillary permeability and altering the rate of absorption of venom from the site while other agents may alleviate neurotoxicity or reduce haemotoxicity of venoms on the system. The present study was undertaken to evaluate the beneficial effect of (1) ‘Betnesol’ (Glaxo brand of betamethasone), (2) Neostigmine bromide (E Merck) and (3) Calcium gluconate – 10% (Sandoz) in experimental envenomation with cobra venom (Naja naja) in adult rats of both sexes. One LD50 cobra venom (0.097 mg per 100 g body weight – death within 8 hours) was given intramuscularly to these experimental rats and the trial drugs viz., ‘Betnesol’ (0.6, 0.8 and 1 mg per 100 g body weight), neostigmine bromide (30 mcg per 100 g body weight) and calcium gluconate (8,10 and 12 mg per 100 g body weight) were given intraperitoneally at varying intervals to evaluate the efficacy to these drugs in respect of their ability to prolong the survival period of experimentally envenomated rats. It is observed that ‘Betnesol’ at dose rate of 0.8 to 1 mg per 100 g body weight of rate when given immediately after injection of one LD50 cobra venom gave 100 percent prolongation of survival period and the degree of protection decreases when the time lag for the administration of this drug. Neostigmine bromide was found to be of not much value to counteract the neurotoxicity produced by cobra venom. Results of calcium administration were of a varying nature and require further investigation. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Nair K P D (Guide) |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | http://krishikosh.egranth.ac.in/handle/1/2040963 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | |
| Koha item type | Theses |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Permanent Location | Current Location | Shelving location | Date acquired | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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| KAU Central Library, Thrissur | KAU Central Library, Thrissur | Theses | 2014-03-18 | 636.089 5 VEN/ST | 170025 | 2014-03-18 | 2014-03-18 | Theses |