Studies on the Effect of Corticosteroids, Neostigmine and Calcium in Cobra Venom (Naja naja) Intoxication
By: Venugopalan K.
Contributor(s): Nair K P D (Guide).
Material type:
BookPublisher: Mannuthy Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences 1975DDC classification: 636.089 5 Online resources: Click here to access online Dissertation note: MVSc Abstract: Administration of specific antiserum as early as possible after snake bite is of utmost importance for better chances of survival. Supportive measures are definitely capable of reducing the venom toxicity And prolonging survival period eg., if the absorption of venom from the site of bite could be delayed or retarded it will be highly beneficial to the patient. It has been shown that certain drugs are capable of decreasing capillary permeability and altering the rate of absorption of venom from the site while other agents may alleviate neurotoxicity or reduce haemotoxicity of venoms on the system.
The present study was undertaken to evaluate the beneficial effect of (1) ‘Betnesol’ (Glaxo brand of betamethasone), (2) Neostigmine bromide (E Merck) and (3) Calcium gluconate – 10% (Sandoz) in experimental envenomation with cobra venom (Naja naja) in adult rats of both sexes. One LD50 cobra venom (0.097 mg per 100 g body weight – death within 8 hours) was given intramuscularly to these experimental rats and the trial drugs viz., ‘Betnesol’ (0.6, 0.8 and 1 mg per 100 g body weight), neostigmine bromide (30 mcg per 100 g body weight) and calcium gluconate (8,10 and 12 mg per 100 g body weight) were given intraperitoneally at varying intervals to evaluate the efficacy to these drugs in respect of their ability to prolong the survival period of experimentally envenomated rats.
It is observed that ‘Betnesol’ at dose rate of 0.8 to 1 mg per 100 g body weight of rate when given immediately after injection of one LD50 cobra venom gave 100 percent prolongation of survival period and the degree of protection decreases when the time lag for the administration of this drug. Neostigmine bromide was found to be of not much value to counteract the neurotoxicity produced by cobra venom. Results of calcium administration were of a varying nature and require further investigation.
| Item type | Current location | Call number | Status | Date due | Barcode |
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Theses
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KAU Central Library, Thrissur Theses | 636.089 5 VEN/ST (Browse shelf) | Available | 170025 |
MVSc
Administration of specific antiserum as early as possible after snake bite is of utmost importance for better chances of survival. Supportive measures are definitely capable of reducing the venom toxicity And prolonging survival period eg., if the absorption of venom from the site of bite could be delayed or retarded it will be highly beneficial to the patient. It has been shown that certain drugs are capable of decreasing capillary permeability and altering the rate of absorption of venom from the site while other agents may alleviate neurotoxicity or reduce haemotoxicity of venoms on the system.
The present study was undertaken to evaluate the beneficial effect of (1) ‘Betnesol’ (Glaxo brand of betamethasone), (2) Neostigmine bromide (E Merck) and (3) Calcium gluconate – 10% (Sandoz) in experimental envenomation with cobra venom (Naja naja) in adult rats of both sexes. One LD50 cobra venom (0.097 mg per 100 g body weight – death within 8 hours) was given intramuscularly to these experimental rats and the trial drugs viz., ‘Betnesol’ (0.6, 0.8 and 1 mg per 100 g body weight), neostigmine bromide (30 mcg per 100 g body weight) and calcium gluconate (8,10 and 12 mg per 100 g body weight) were given intraperitoneally at varying intervals to evaluate the efficacy to these drugs in respect of their ability to prolong the survival period of experimentally envenomated rats.
It is observed that ‘Betnesol’ at dose rate of 0.8 to 1 mg per 100 g body weight of rate when given immediately after injection of one LD50 cobra venom gave 100 percent prolongation of survival period and the degree of protection decreases when the time lag for the administration of this drug. Neostigmine bromide was found to be of not much value to counteract the neurotoxicity produced by cobra venom. Results of calcium administration were of a varying nature and require further investigation.
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