Immunopathological response of the Japanese Quail (Coturnix coturnix japonica) in experimental Aflatoxicosis
By: Sureshkumar M.
Contributor(s): Divakaran Nair N (Guide).
Material type:
BookPublisher: Mannuthy Centre of Excellence in Pathology, College of Veterinary and Animal Sciences 1999DDC classification: 636.089 6 Online resources: Click here to access online Dissertation note: MVSc Abstract: One month old Japanese quails vaccinated with Ranikhet
disease vaccine (Lasota strain) on 7th day, were divided into
three groups viz., A, B and C of 35 birds each for assessing
the immunopathological responses in experimental
aflatoxicosis. Birds of group Band C were administered
aflatoxin Bl by oral intubation at the rate of 0.5 ppm twice
weekly for two months and group .A were vaccinated with R2B
strain vaccine at the age of 46 days. Seven birds from each
group were sacrificed at fortnightly intervals for the
evaluation of various organ weights, haematological,
biochemical and haemagglutination inhibition titre values.
Liver weights and spleen weights were significantly
increased in the toxin treated birds while bursal weights were
significantly depressed from that of controls. Packed cell
volume, erythrocyte count and leucocyte counts were
significantly increased in the toxin treated birds at the end
of the experiment with a significant increase in erythrocyte
sedimentation rate at the 45th and 60th day of the experiment.
A relative heterophilia and lymphopenia were observed in the
toxin treated birds.
Serum total protein, albumin and globulin levels were
significantly depressed in the toxin treated birds but the
albumin-globulin ratio was unaltered. A relative decrease in
the haemagglutination inhibition titre values of the toxin
treated birds was recorded.
The gross and histopathological lesions in the liver of
the toxin treated birds were suggestive of progressive hepatic
degeneration, necrosis and fatty changes. There was lymphoid
depletion and vascular sclerosis in the spleen while the
bursae of the treated birds showed lymphoid depletion,
necrosis of lymphocytes, intra and interfollicular cyst
formation in increasing intensities in a time dependant
manner.
The pathomorphological alterations and a relative
depression of HI titres in the aflatoxin treated quails
indicates a moderate depression of the immune status by
aflatoxin at such a low dose level.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
|
KAU Central Library, Thrissur Theses | 636.089 6 SUR/IM (Browse shelf) | Available | 171477 |
MVSc
One month old Japanese quails vaccinated with Ranikhet
disease vaccine (Lasota strain) on 7th day, were divided into
three groups viz., A, B and C of 35 birds each for assessing
the immunopathological responses in experimental
aflatoxicosis. Birds of group Band C were administered
aflatoxin Bl by oral intubation at the rate of 0.5 ppm twice
weekly for two months and group .A were vaccinated with R2B
strain vaccine at the age of 46 days. Seven birds from each
group were sacrificed at fortnightly intervals for the
evaluation of various organ weights, haematological,
biochemical and haemagglutination inhibition titre values.
Liver weights and spleen weights were significantly
increased in the toxin treated birds while bursal weights were
significantly depressed from that of controls. Packed cell
volume, erythrocyte count and leucocyte counts were
significantly increased in the toxin treated birds at the end
of the experiment with a significant increase in erythrocyte
sedimentation rate at the 45th and 60th day of the experiment.
A relative heterophilia and lymphopenia were observed in the
toxin treated birds.
Serum total protein, albumin and globulin levels were
significantly depressed in the toxin treated birds but the
albumin-globulin ratio was unaltered. A relative decrease in
the haemagglutination inhibition titre values of the toxin
treated birds was recorded.
The gross and histopathological lesions in the liver of
the toxin treated birds were suggestive of progressive hepatic
degeneration, necrosis and fatty changes. There was lymphoid
depletion and vascular sclerosis in the spleen while the
bursae of the treated birds showed lymphoid depletion,
necrosis of lymphocytes, intra and interfollicular cyst
formation in increasing intensities in a time dependant
manner.
The pathomorphological alterations and a relative
depression of HI titres in the aflatoxin treated quails
indicates a moderate depression of the immune status by
aflatoxin at such a low dose level.
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