Immunopathologic and toxic effects of endosulfan in chick embryo
By: Kalai Selvan P.
Contributor(s): Divakaran Nair N (Guide).
Material type:
BookPublisher: Mannuthy Centre of Excellence in Pathology, College of Veterinary and Animal Sciences 2004DDC classification: 636.089 6 Online resources: Click here to access online Dissertation note: MVSc Abstract: The present study was undertaken to investigate the immunopathologic and toxic
effects of endosulfan in chick embryo. The embryos were exposed to endosulfan at
various dose levels through different routes.
The weight of the embryo, bursa, thymus and spleen, histopathology of the
lymphoid organs, liver, kidney and brain and quantification of the preformed maternal
IgY level in the egg yolk were the parameters analysed to study the effects.
Endosulfan was found to be teratogenic at the grven dose levels. The
abnormalities observed were agenesis of beak, crossed beak, short lower beak,
eventration of viscera and curled toe.
Endosulfan did not cause any significant gross changes in the developing embryos
except mild haemorrhages. Endosulfan treatment did not produce any significant
reduction in the weight of the embryos as well as the weight of the lymphoid organs.
On histopathological examinations endosulfan was found to be nephrotoxic and
hepatotoxic to the embryos. Varying degrees of degeneration and necrosis was evident in
kidney and liver. Effect on the bursa, thymus and spleen were mild to moderate where in
the degenerative changes predominated. Dose dependent increase in the involution
process of the thymus as evidenced by increase in the Hassal's zone was observed. The
lesions in the developing lymphoid organs reflected that endosulfan is toxic to the system
and going to affect the immunocompetency by way of immunosuppression and thereby
rendering the chicks susceptible to various diseases. The study indicated that the
endosulfan treatment did not have any effect on the preformed maternal immunoglobulin
level in the egg yolk.
| Item type | Current location | Call number | Status | Date due | Barcode |
|---|---|---|---|---|---|
Theses
|
KAU Central Library, Thrissur Theses | 636.089 6 KAL/IM (Browse shelf) | Available | 172283 |
MVSc
The present study was undertaken to investigate the immunopathologic and toxic
effects of endosulfan in chick embryo. The embryos were exposed to endosulfan at
various dose levels through different routes.
The weight of the embryo, bursa, thymus and spleen, histopathology of the
lymphoid organs, liver, kidney and brain and quantification of the preformed maternal
IgY level in the egg yolk were the parameters analysed to study the effects.
Endosulfan was found to be teratogenic at the grven dose levels. The
abnormalities observed were agenesis of beak, crossed beak, short lower beak,
eventration of viscera and curled toe.
Endosulfan did not cause any significant gross changes in the developing embryos
except mild haemorrhages. Endosulfan treatment did not produce any significant
reduction in the weight of the embryos as well as the weight of the lymphoid organs.
On histopathological examinations endosulfan was found to be nephrotoxic and
hepatotoxic to the embryos. Varying degrees of degeneration and necrosis was evident in
kidney and liver. Effect on the bursa, thymus and spleen were mild to moderate where in
the degenerative changes predominated. Dose dependent increase in the involution
process of the thymus as evidenced by increase in the Hassal's zone was observed. The
lesions in the developing lymphoid organs reflected that endosulfan is toxic to the system
and going to affect the immunocompetency by way of immunosuppression and thereby
rendering the chicks susceptible to various diseases. The study indicated that the
endosulfan treatment did not have any effect on the preformed maternal immunoglobulin
level in the egg yolk.
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