1. KAUTIR (Kerala Agricultural University Theses Information and Retrieval)
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Item Investigations on etio-pathology of vomiting in dogs(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2001) Muraly, P; Baby, P GThe study "INVESTIGATIONS ON ETIO-PATHOLOGY OF VOMITING IN DOGS" was conducted in 20 dogs to evaluate ultrasonography and radiography as diagnostic tools in vomiting dogs; to assess hydration status, electrolyte and acid-base balance in vomiting dogs and to correlate clinico-pathologic findings with radiographic and ultrasonographic changes. Various parameters such as history, physical examination, hydration status, ultrasonography, radiography-plain and contrast, haematology, serum biochemistry, and wherever possible histopathology were studied. Most of the dogs under study had bile stained watery vomitus but dogs with pyloric stenosis had frothy or watery white vomitus. The frequency of vomiting in dogs with gastritis and gastrointestinal (GI) obstruction was two to seven times per day, it was variable in dogs with hepatic and renal disorders, but was associated with food intake in dogs with pyloric stenosis. Physical examination was found useful in dogs with GI obstruction, while it was non-specific in dogs with gastritis and renal disorders. Capillary refill time (CRT) and degree of sunken eye balls were helpful to assess dehydration. Estimation of volume of packed red cells (VPRC) was found beneficial to assess dehydration unless the dogs are anemic. Ultrasonography could not identify any lesions in dogs with gastritis, but was useful to detect GI obstructions due to pyloric stenosis, intussusception and foreign body and to characterise lesions in the parenchymal organs like liver and kidney. While plain radiographs could give indication to possible non-radiopaque GI obstructions, contrast radiography was required to confirm. Radiography could not identify any lesions in dogs with gastritis, hepatic and chronic intestitial nephritis. Hypokalemia with metabolic alkalosis was the significant electrolyte and acid-base derangement in dogs with vomiting due to gastritis and GI obstructions.Item Etiopahtogenesis and therapeutic management of thiamine responsive caprine polioencaphalomalacia(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2002) Usha Narayana Pillai; Alex, P CItem Dermatological disorders in dogs(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 1999) Madhu Rajan Mathews; Aleyas, N MItem Clinico-therapeutic study of ruminal lactic acidosis in goats(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2000) Anil Thachil, J; Baby, P GTwelve goats with history and symptoms suggestive of ruminal acidosis were divided into two groups (I and 11). Six healthy goats were also served as controls. Detailed clinical examination, recording of clinical data, sampling and analysis of rumen liquor and blood were done at zero hour, one hour, 12 h, 24 h, 48 hand 72 h of the study. Therapeutic management of group I was done by giving five per cent sodium bicarbonate solution intravenously at a dose rate of 5 ml / kg ; whereas in group 11 it was replaced with a mixture of sodium carbonate and sodium bicarbonate (carbicarb) intravenously at a dose rate of 4 ml / kg. Animals of group I and 11 were given dexamethasone 20 mg intravenously, evacuated rumen contents and given .. magnesium hydroxide and oxytetracycline orally. Supportive treatments were done with fluids, vitamin B complex inj ection daily and transfer of fresh rumen liquor on second or third day in both groups. The clinical signs noticed were anorexia, dullness, low carriage of head, dry muzzle, sunken eyes, tending of skin, oliguria, distended abdomen, cold extremities and retracted eye balls. There was improvement in the pulse quality and also considerable reduction in respiratory rate noticed in animals of group 11 than in group I at 24 h of .treatment. In both groups, the rumen liquor colour, odour, consistency and protozoal motility became normal, SAT and MBRT showed improvement and elevated rumen liquor lactic acid became normal by 72 h. Elevated haemoglobin, PCV, TEC, TLC and neutrophilia also became normal. Improvement in serum bicarbonate level was marked in group 11 than in group I at 24 hand 48 h of treatment. Serum lactic acid showed significant increase at zero hour in group I and 11, but came to normal in group 11 at 72 h, but not in group I. Elevated serum protein level at zero hour also came to normal. Clinical assessment throughout the study revealed that all animals of group 11 appeared more alert and active and recovered earlier than in group I.Item Ultrasonographic evaluation of canine hepatic disorders(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2003) Renjith, R; Alex, P CStudy on 'Ultrasonographic evaluation of canine hepatic disorders' was conducted on forty eight dogs to evaluate the utility of ultrasonography as a tool for early and better diagnosis of liver diseases and classify liver diseases based on ultrasonographic findings. Parameters studied were history and clinical signs, physical examination, ultrasonography of liver, ultrasound guided biopsy, haematology and serum biochemistry, post-mortem examination and histopathology. Specific clinical signs noticed were ascites and icterus. Physical examination revealed abdominal distension, yellowish discolouration of skin and hepatomegaly. Primary liver disorders identified by ultrasound scans were haematoma, lymphosarcoma, hepatitis due to leptospirosis, cirrhosis, fibrosis, fatty infiltration, chronic active hepatitis, portal hypertension and portosystemic shunt. Secondary changes noticed in liver were due to pyometra, proctitis and cholecystitis, hepatic calcification in chronic renal failure and passive venous congestion in right sided heart failure. Ultrasound guided biopsy confirmed lymphosarcoma, fatty infiltration and , chronic active hepatitis. Histological changes in leptospirosis were chronic venous . and sinusoidal congestion whereas ~n cirrhosis, fibrosis and pseudo lobulation were the prominent histological change. Alkaline phosphatase and Alanine aminotransferase levels were above normal values in all the cases studied. From the present study it was inferred that ultrasonography was a valuable tool for diagnosing hepatopathies along with clinico-pathological and ultrasound guided biopsy.Item Studies on non-specific anorexa in cattle(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 1989) Baby, P G; Alikutty, K MNon – specific anorexia as a peculiar clinical syndrome in cattle was observed for the last one and a half decades in Kerala. Sample survey on the incidence of this syndrome was conducted through the selected veterinary hospitals in the field and of the Kerala Agricultural University. During the period of 1978 – 1982, anorexia syndrome in cattle constituted 10.95 per cent of the total and 32.30 per cent of their digestive disorders. The incidence of the syndrome was also noted high during the months of November to April every year. Ten apparently healthy cattle maintained under identical conditions of feeding and management at the University Livestock Farm, Mannuthy were selected at random and used as the control animals (Group I) for this study. Twenty selected clinical cases of non – specific anorexia presented at the University Hospital, Mannuthy were divided into groups of ten each (Group II and GroupIII) and utilized for these investigations. Course of the disease was followed and samples of rumen liquor and blood were collected and analysed on the first, third and fifth days of their admission in the clinic. Inappetance, mucopurulent nasal discharge, dryness of the muzzle, followed by peeling of its epithelium, constipation or diarrhea, weakness, emaciation and also marked reduction in milk yield in the lactating animals were the clinical manifestations noted in the affected animals. Their rectal temperature was normal, pulse weak and rapid, respiration normal but sometimes labored and visible mucous membranes were pale or became icteric in the later stages of the disease. Rate of rumen motility was reduced and feeble in strength with rumination remaining suspended. Animals of group II were given conventional therapy comprising oral administration of alksline stomachics. Animals of group III were given 25 per cent dextrose solution and vitamin B – complex with liver extract parenterally and stomachics orally on the first, third and fifth days of their admission in the clinic. Rumen liquor of animals of groups II and III was light yellow, olive green or greenish in colour, aromatic / offensive in odour and thick/thin in consistency on the first day of observation. Protozoal motility was poor (+) to vigorous (+++) and sedimentation activity time was prolonged significantly on the first day. The mean pH of the rumen Liquor of these animals was not significantly different from that of the healthy group. Increase in the ammonia nitrogen level and decrease in total volatile fatty acids concentration in the rumen liquor observed on the first day were significant. Blood glucose, total bilirubin, total protein, albumin and albumin/globulin ratio in the serum were changed significantly in animals with non – specific anorexia. Significant changes observed in the above parameters in group II animals were further enhanced on third and fifth days of observation. In group III animals, a decrease in the ammonia nitrogen level and increase in the total volatile fatty acids concentration in the rumen liquor observed on the third and fifth day of admission in the clinic was statistically significant. Blood glucose, albumin – globulin ratio in the serum were also increased significantly in group III animals on fifth day. Following modified line of therapy the animals of group III became normal within three to five days. Clinical improvement was indicated by increased appetite, revival of rumen motility and rumination and also increased milk yield in the lactating animals. Decrease in the ammonia nitrogen level and increase in the total volatile fatty acids concentration in the rumen liquor of group III animals were significant on fifth day of therapy. Increase in blood glucose, albumin, albumin ratio in the serum were also found to be statistically significant on the fifth day. The changes in the blood glucose, total bilirubin, total protein, albumin and albumin – globulin ratio in the serum indicated hepatic insufficiency possibly responsible for the anorexia developed in the diseased animals. The modified line of therapy was found to be superior to conventional therapy for the clinical management of non – specific anorexia in cattle.Item Investigation on sudden death in pigs(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2006) Manjusha, A; Baby, P GStudy of “Investigation on sudden death in pigs’’ was conducted in pigs from various pig farms in Kerala, where cases of sudden death were reported. In these farms around 12.4 per cent of the total pigs were lost due to sudden death. Post mortem examination were carried out in six animals. Clinical materials were collected from the forty-five contact animals and six apparently healthy control animals. Occurrences of sudden death were common in three to six month old piglets. Most of the animals died without any premonitory clinical signs. All these animals were fed with uncooked swill mainly containing chicken waste. Some of the contact animals showed clinical signs like elevated temperature, congested mucous membranes and diarrhoea. On cultural examination of the samples from the two farms growth of the gram-negative organisms were obtained. Transmission of these organisms to these pigs may be from the uncooked swill fed to them. On antibiotic sensitivity testing cefotaxime and ceftriaxone were found to be effective against these organisms. Leukocytoses with neutrophilia were observed in animals of group III where as normal leukogram observed in animals of group II. Serum biochemical studies revealed an elevated level of creatine kinase, lactate dehydrogenase and aspartate aminotransaminase in animals without any obvious clinical sign of illness, indicating involvement of heart in the pathological condition. Animals with obvious clinical signs of illness revealed an elevated level of lactate dehydragenase, indicating damage of the tissues. Gross pathology on post mortem revealed lesions in heart, liver, brain, lymph nodes and kidney. Haemorrhages in the heart were the major findings. Prominent histopathological changes were noticed in heart and brain. Heart showed varying degrees of inflammation, degeneration and necrosis. Stomach, intestine, lung, liver and kidney also showed pathological changes. For all the animals under study supplementation of mineral mixture containing vitamin E and Selenium were advised. Animals with clinical signs of illness were treated with cefotaxime. It prevented further mortality in these farms.Item Metabolic profile of hypogalactic cows(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 2006) Reena George; Baby, P GA study of the metabolic profile of hypogalactic dairy cows under field conditions was undertaken. Thirty cases of hypogalactic cows were selected and utilised for the study. Similarly, six healthy dairy cows maintained under identical environmental and managemental conditions constituted the control group. Samples of blood, urine and milk were collected and analysed for various parameters according to standard methods. Data collected from the hypogalactic dairy cows indicated a high incidence in animals of third parity which were around four to five years of age. The clinical data were within normal limits. Haemoglobin was decreased indicating a mild anaemia. Biochemically, serum glucose, total protein, albumin, globulin and calcium showed a significant decrease. Blood ketone body levels and serum aspartate aminotransferase (AST) levels showed significant increase. Serum magnesium and phosphorus levels did not vary significantly. The metabolic profile of hypogalactic animals revealed that hypoglycaemia, hypocalcaemia, hypoproteinemia and subclinical ketosis may be the possible causes of hypogalactia.Item Role of selected minerals in ruminal indigestion in cross-bred cattle(Department of Clinical Medicine, College of Veterinary and Animal Sciences, Mannuthy, 1983) George Thomas; Alikutty, K Metc. The present investigations were taken up with the objectives to survey the incidence and seasonal dynamics of digestive disorders in cattle in Kerala, to study the associated changes in physical characters, Ph, protozoal motility and sedimatnation activity time of rumen liquor and the status of selected minerals in rumen liquor and blood in clinical cases of simple indigestion in crose – bred cattle and based on the findings in the above to modify and compare the line of therapy for the same. Date collected from selected veterinary hospitals in the field and under the Kerala Agricultural University showed that digestive disorders formed 33.10 per cent of the total of the incidence of diseases in cattle. Among the digestive disorders, cases of indigestion as a whole were 70.07 per cent and simple indigestion mostly associated with dietetic errors were 48.90 per cent. Influence of season on the incidence of these conditions was significant, being highest in summer. This could be attributed to irregularities in with non – availability of good quality fodder throughout the year and feeding cattle predominantly on dry and coarse locally available unconventional animal rations and inadequate supply of water during the season. Eight apparently healthy adult cross-bred cattle from the University Livestock Farm, Mannuthy, formed the healthy control animals (Group I). Twelve clinical cases of simple indigestion in adult cross – bred cattle divided at random into two groups of six each constituted the treatment groups (Group II and III). In Group II animals conventional therapy consisting of bitter stomachics orally and liver extract parenterally was tried. In animals of group III modified therapy comprising of bitter stomachics and ‘Anorexon’ (pfizer pvt. Ltd.) tablets orally and ‘Calborol’ (M & B pvt. Ltd.) intravenously was adopted. Course of the disease was studied and samples of rumen liquor and blood were collected for analysis on the first, fourth and seventh day of admission in the clinic. Important clinical signs of the disease were slight general depression and dullness, partial or complete loss of appetite, suspension of rumination, cessation or depressed rumen contractions, normal or pesty and scanty dung or presence of mild diarrhoes and drop in milk yield. The body temperature and rates of pulse and respiration were normal. Physical characters of the rumen liquor from cattle with simple indigestion were altered in that the colour was brownish yellow/brownish with faintly aromatic/faintly sour odour and thin/thick consistency compared to the greenish yellow colour, aromatic odour and thick consistency of rumen liquor from healthy control animals. Protozoal motility was suppressed (slow (+) to moderate (++) and SAT was prolonged to 26.16 + 1.70 minutes. Levels of calcium, phosphorus and magnesium in the rumen liquor and blood were significantly reduced (P < 0.01) in the cases studied. However, the levels of sodium and potassium did not show any significant variations before, during or after therapy. Mean calcium, phosphorus, magnesium, sodium and potassium levels of rumen liquor in affected animals were 10.20 + 0.37 mg/dl, 7.76 + 0.23 mg/dl, 5.85 + 0.20 mg/dl, 132.33 + 1.17 mEg/L and 23.93 + 1.74 mEg/L respectively and the corresponding values in blood were 10.17 + 0.096 mg/dl, 5.17 + 0.093 mg/dl, 2.12 + 0.28 mg/dl, 150.35 + 1.30 mEg/L and 4.61 + 0.13 mEg/L. Physical characters, protozoal motility and SAT of the rumen liquor have almost returned to normal ranges following therapy. Improvements in calcium, phosphorus and magnesium level in rumen liquor and blood could presumably be associated with revivel of appetite and increased intake of feed following therapy. On the basis of better clinical response as judged by early return of appetite and milk yield, better improvements in the microbial activity of rumen liquor and mineral status of rumen liquor and blood and shorter recovery period, the modified therapy was found superior to the conventional therapy for the clinical management of simple indigestion in cross – bred cattle.Item Neurological investigation and treatment of polioencephalomalacia affected goats(Department of Clinical Medicine, College of Veterinary and Animal Sciences, 2000) Arun George; Alex, P CSeven goats diagnosed to be suffering from polioencephalomalacia were used for the present study. It included detailed clinical and neurological examination, CSF collection and analysis, electroencephalography, cranial radiography, histopathology of brain and assessment of the therapeutic efficacy of thiamine hydrochloride intravenously and bismuth carbonate orally in PEM cases. History of the affected animals suggested that feeding of rice gruel (a carbohydrate rich diet) could be one of the predisposing causes for the development of PEM of goats in Kerala. The characteristic clinical signs were head tilt, lateral deviation of head, nystagmus, circling, staggering gait, broad based stance and lying only on one side. Nervous system examination revealed depressed behaviour and deficits in posture and gait. Majority of the cranial nerves did not show deficits. Defects in postural reaction and abnormalities in spinal cord reflexes were detected. CSF examination revealed a significant increase in the mean total protein concentration and a non-significant increase in the total leucocyte count. Electroencephalograms revealed continuous slow waves and asynunetric waves. Another abnormality was high amplitude slow activity. Histopathology of brain revealed necrosis of neurons of the pyramidal and fusiform cell layers of the cerebral cortex with neuronophagia, satellitosis, perivascular oedema, perivascular cuffing and eovascularisation of grey matter. Out of the seven cases, six animals responded to the treatment with thiamine hydrochloride at the rate of 50 mg/kg body weight twice daily intravenously and bismuth carbonate, 15g per animal, orally as a drench for four days.